Space-weighted seismic attenuation mapping of the aseismic source of Campi Flegrei 1983-84 unrest

Peer reviewedPublisher PD

An integrated DC/DC converter with online monitoring of hot-carrier degradation

An integrated DC/DC converter with online monitoring of the degradation induced by hot-carrier stress (HCD) in new generation power LDMOS transistors is proposed. In particular, when a relatively high drain voltage is applied during on-state regime (switching phase), degradation mechanisms lead to an increase of the transistor on-resistance (RON). To this purpose, the converter is able to dynamically estimate the RON of the power LDMOS and to provide its value to the user during normal operation. The presented solution, developed in STMicroelectronics 90nm BCD technology, features a non-invasive current sensing and voltage sampling architecture, which is applied to a common DC/DC boost converter to evaluate the resistance of the power LDMOS. Without lack of generality, this specific sensing structure can be applied to any kind of converter, e.g. buck or buck-boost, as it does not require any change in the main conversion circuit

An Automatic Offset Correction Platform for High-Throughput Ion-Channel Electrophysiology

High-throughput ion channel screening for drug discovery is at the base of the recent shift of resources in the pharmaceutical industry towards addressing drug safety issues earlier in the discovery process. Very few examples of parallel ion-channel recording platforms are currently present in literature, due to the complexity of the setup. However, single-junction Ag/AgCl electrodes suffer of intrinsic voltage offsets, due to the electrode-buffer interface variability. This is very critical, since ion- channel recording requires high accuracy (pA resolution) within the full-scale (nA range), limiting the operability of the measurement, especially on a multi-channel approach. This paper presents an automatic offset correction system fully implemented on a lipid bilayer membrane platform. The platform allows offset-free recording of ion-channel signals acquired and displayed by means of a graphical user interface

Non-Invasive Estimation of Plasma Sodium Concentration During Hemodialysis via Capacitively-Coupled Electrical Impedance Spectroscopy

This paper presents a compact, low-cost, and noninvasive system for real-time estimation of plasma sodium concentration ([Na]Pl) during a hemodialysis (HD) session with state-of-the-art accuracy. It is based on electrical impedance spectroscopy (EIS) performed with a capacitively-coupled impedance sensing cell and a high-frequency measurement device, both custom-built. The EIS data are processed to infer the resistance of the liquid inside the cell, which is used together with an optical hemoglobin sensor to estimate the [Na]Pl. Validation of the EIS was performed by estimating the conductivity of bloodmimicking fluid (BMF). The complete method was validated using whole bovine blood, comparing the results to those obtained with standard instruments. The system was able to estimate the [Na]Pl with sufficient accuracy (RMS error of 3.0 mol/m3 with respect to reference data) to provide clinically useful information. The proof-of-concept hardware can be converted to a cheap and compact circuit board for integration into an HD machine

THE IMPLANT TREATMENT OF TWO PATIENTS SUFFERING FROM SJÖGREN’S SYNDROME WITH MULTIFACTORIAL REGENERATIVE PROTOCOL

The purpose of the work is to show that it is possible to rehabilitate with Multifatorial Regenerative Protocol (MFRP) also the patients with diseases considered to be absolute contraindications to the implant rehabilitation. For the rehabilitation it has been used the PBR rehabilitation technique, that allows to insert prosthetic roots not excessively traumatizing the bone tissue and to avoid the use of high speed rotary burs. Despite the disease and the poor bone quality, it has been possible to obtain the osteo-connection only in 45 days. Using the MFRP implants, it is possible to rehabilitate with a high percentage of success also patients with poor bone quality and density

Development of an electrical impedance tomography set-up for the quantification of mineralization in biopolymer scaffolds

Objective. 3D cell cultures are becoming a fundamental resource for in-vitro studies, as they mimic more closely in-vivo behavior. The analysis of these constructs, however, generally rely on destructive techniques, that prevent the monitoring over time of the same construct, thus increasing the results variability and the resources needed for each experiment. Approach. In this work, we focus on mineralization, a crucial process during maturation of artificial bone models, and propose electrical impedance tomography (EIT) as an alternative non-destructive approach. In particular, we discuss the development of an integrated hardware/software system capable of acquiring experimental data from 3D scaffolds and reconstructing the corresponding conductivity maps. We also show how the same software can test how the measurement is affected by biological features such as scaffold shrinking during the culture. Main results. An initial validation, comprising the acquisition of both a non-conductive phantom and alginate/gelatin scaffolds with known calcium content will be presented, together with the in-silico study of a cell-induced mineralization process. This analysis will allow for an initial verification of the systems functionality while limiting the effects of biological variability due to cell number and activity. Significance. Our results show the potential of EIT for the non-destructive quantification of matrix mineralization in 3D scaffolds, and open to the possible long term monitoring of this fundamental hallmark of osteogenic differentiation in hybrid tissue engineered constructs

A broadband current sensor based on the X-Hall architecture

A broadband current sensor, which is fully integrated and galvanically-isolated, is presented in this paper. The current sensor relies only on a Hall-effect probe to realize the magnetic sensing core so as to minimize the cost and the occupied space. Bandwidth limitations of state-of-the-art Hall-effect probes are overcame by combining the novel X-Hall architecture with a wide bandwidth differential-difference current-feedback amplifier. A prototype implemented in 0.16 \u3bcm BCD technology demonstrates a bandwidth wider than 20 MHz. Offset, sensitivity and power consumption are comparable to the state of the art. This is the first Hall-only current sensor achieving a bandwidth higher than 3 MHz

Slow earthquakes and low frequency tremor along the Apennines, Italy

This paper reviews the main observations on slow earthquakes and low frequency tremor made along the Apennines, the main seismic active zone of Italy. These observations have been made using a geodetic interferometer system operating since 1994 in the underground tunnel of Gran Sasso, central Italy, and an underground seismic array (UNDERSEIS) operating since 2002 in the same environment. The observations made in recent years indicate that both phenomena are quite rare and apparently uncorrelated. Slow earthquakes, mainly recorded in 1997 and occasionally later, have probably been caused by the activity of a shallow fault system located near the interferometers. Until now only one tremor episode characterized by low frequency content and duration of several hours has been detected in January 2004, without any correlations with the occurrence of slow or regular earthquakes. The signal to noise ratio of this event is very low, but the results of our detailed analysis show that its frequency contents and wave field characteristics are compatible with a low frequency non volcanic tremor

Crack-Like Processes Governing the Onset of Frictional Slip

We perform real-time measurements of the net contact area between two blocks of like material at the onset of frictional slip. We show that the process of interface detachment, which immediately precedes the inception of frictional sliding, is governed by three different types of detachment fronts. These crack-like detachment fronts differ by both their propagation velocities and by the amount of net contact surface reduction caused by their passage. The most rapid fronts propagate at intersonic velocities but generate a negligible reduction in contact area across the interface. Sub-Rayleigh fronts are crack-like modes which propagate at velocities up to the Rayleigh wave speed, VR, and give rise to an approximate 10% reduction in net contact area. The most efficient contact area reduction (~20%) is precipitated by the passage of slow detachment fronts. These fronts propagate at anomalously slow velocities, which are over an order of magnitude lower than VR yet orders of magnitude higher than other characteristic velocity scales such as either slip or loading velocities. Slow fronts are generated, in conjunction with intersonic fronts, by the sudden arrest of sub-Rayleigh fronts. No overall sliding of the interface occurs until either of the slower two fronts traverses the entire interface, and motion at the leading edge of the interface is initiated. Slip at the trailing edge of the interface accompanies the motion of both the slow and sub-Rayleigh fronts. We might expect these modes to be important in both fault nucleation and earthquake dynamics.Comment: 19 page, 5 figures, to appear in International Journal of Fractur

Enhancing Egress Drills: Preparation and Assessment of Evacuee Performance

This article explores how egress drills-specifically those related to fire incidents-are currently used, their impact on safety levels, and the insights gained from them. It is suggested that neither the merits of egress drills are well understood, nor the impact on egress performance well characterized. In addition, the manner in which they are conducted varies both between and within regulatory jurisdictions. By investigating their strengths and limitations, this article suggests opportunities for their enhancement possibly through the use of other egress models to support and expand upon the benefits provided. It is by no means suggested that drills are not important to evacuation safety-only that their inconsistent use and the interpretation of the results produced may mean we (as researchers, practitioners, regulators, and stakeholders) are not getting the maximum benefit out of this important tool